RT Journal Article
T1 Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.
A1 Rodríguez, Víctor
A1 Martín, Jesús
A1 Sarmiento-Vizcaíno, Aida
A1 de la Cruz, Mercedes
A1 García, Luis A
A1 Blanco, Gloria
A1 Reyes, Fernando
K1 Cantabrian Sea
K1 Streptomyces cyaneofuscatus
K1 anthracimycin
K1 deep-sea actinobacteria
AB The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic.
YR 2018
FD 2018-10-25
LK http://hdl.handle.net/10668/13136
UL http://hdl.handle.net/10668/13136
LA en
DS RISalud
RD Apr 8, 2025