%0 Journal Article
%A Rodríguez, Víctor
%A Martín, Jesús
%A Sarmiento-Vizcaíno, Aida
%A de la Cruz, Mercedes
%A García, Luis A
%A Blanco, Gloria
%A Reyes, Fernando
%T Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.
%D 2018
%U http://hdl.handle.net/10668/13136
%X The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic.
%K Cantabrian Sea
%K Streptomyces cyaneofuscatus
%K anthracimycin
%K deep-sea actinobacteria
%~