RT Journal Article
T1 Effect of continuous positive airway pressure on inflammatory, antioxidant, and depression biomarkers in women with obstructive sleep apnea: a randomized controlled trial.
A1 Campos-Rodriguez, Francisco
A1 Asensio-Cruz, Maria Isabel
A1 Cordero-Guevara, Jose
A1 Jurado-Gamez, Bernabe
A1 Carmona-Bernal, Carmen
A1 Gonzalez-Martinez, Monica
A1 Troncoso, Maria F
A1 Sanchez-Lopez, Veronica
A1 Arellano-Orden, Elena
A1 Garcia-Sanchez, Maria Isabel
A1 Martinez-Garcia, Miguel Angel
A1 Spanish Sleep Network, 
K1 biomarkers
K1 continuous positive airway pressure
K1 depression
K1 inflammation
K1 obstructive sleep apnea
K1 oxidative stress
K1 women
AB The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA. We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ≥ 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor α (TNFα), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest. Women had a median (25th-75th percentiles) age of 58 (51-65) years, body mass index 33.5 (29.0-38.3) kg/m2, and AHI 33.3 (22.8-49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNFα levels decreased compared to the control group (-0.29 ± 1.1 vs -0.06 ± 0.53, intergroup difference -0.23 [95% CI = -0.03 to -0.50]; p = 0.043). Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA. NCT02047071.
YR 2019
FD 2019
LK http://hdl.handle.net/10668/14248
UL http://hdl.handle.net/10668/14248
LA en
DS RISalud
RD May 10, 2025