RT Journal Article
T1 Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study
A1 Ordonez-Diaz, Maria Dolores
A1 Gil-Campos, Mercedes
A1 Flores-Rojas, Katherine
A1 Munoz-Villanueva, Maria Carmen
A1 Mesa, Maria Dolores
A1 de la Torre-aguilar, Maria Jose
A1 Gil, Angel
A1 Perez-Navero, Juan Luis
K1 prematurity
K1 extrauterine growth restriction (EUGR)
K1 antioxidants
K1 catalase (CAT)
K1 glutathione peroxidase (GPx)
K1 glutathione reductase (GR)
K1 superoxide dismutase (SOD)
K1 children
K1 For-gestational-age
K1 Oxidative stress markers
K1 Superoxide dismutase
K1 Parenteral-nutrition
K1 Born small
K1 System
K1 Term
K1 Newborns
K1 Obesity
K1 Birth
AB Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants alpha-tocopherol, retinol and beta-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of alpha-tocopherol and beta-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.
PB Frontiers media sa
SN 2296-861X
YR 2021
FD 2021-12-21
LK https://hdl.handle.net/10668/25670
UL https://hdl.handle.net/10668/25670
LA en
DS RISalud
RD Apr 10, 2025