RT Journal Article
T1 Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance.
A1 Rodríguez-Baño, Jesús
A1 Rossolini, Gian Maria
A1 Schultsz, Constance
A1 Tacconelli, Evelina
A1 Murthy, Srinivas
A1 Ohmagari, Norio
A1 Holmes, Alison
A1 Bachmann, Till
A1 Goossens, Herman
A1 Canton, Rafael
A1 Roberts, Adam P
A1 Henriques-Normark, Birgitta
A1 Clancy, Cornelius J
A1 Huttner, Benedikt
A1 Fagerstedt, Patriq
A1 Lahiri, Shawon
A1 Kaushic, Charu
A1 Hoffman, Steven J
A1 Warren, Margo
A1 Zoubiane, Ghada
A1 Essack, Sabiha
A1 Laxminarayan, Ramanan
A1 Plant, Laura
K1 COVID-19
K1 antimicrobial resistance
K1 public health
K1 stewardship
K1 surveillance
AB Antibiotic use in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients during the COVID-19 pandemic has exceeded the incidence of bacterial coinfections and secondary infections, suggesting inappropriate and excessive prescribing. Even in settings with established antimicrobial stewardship (AMS) programmes, there were weaknesses exposed regarding appropriate antibiotic use in the context of the pandemic. Moreover, antimicrobial resistance (AMR) surveillance and AMS have been deprioritised with diversion of health system resources to the pandemic response. This experience highlights deficiencies in AMR containment and mitigation strategies that require urgent attention from clinical and scientific communities. These include the need to implement diagnostic stewardship to assess the global incidence of coinfections and secondary infections in COVID-19 patients, including those by multidrug-resistant pathogens, to identify patients most likely to benefit from antibiotic treatment and identify when antibiotics can be safely withheld, de-escalated or discontinued. Long-term global surveillance of clinical and societal antibiotic use and resistance trends is required to prepare for subsequent changes in AMR epidemiology, while ensuring uninterrupted supply chains and preventing drug shortages and stock outs. These interventions present implementation challenges in resource-constrained settings, making a case for implementation research on AMR. Knowledge and support for these practices will come from internationally coordinated, targeted research on AMR, supporting the preparation for future challenges from emerging AMR in the context of the current COVID-19 pandemic or future pandemics.
YR 2021
FD 2021
LK https://hdl.handle.net/10668/27974
UL https://hdl.handle.net/10668/27974
LA en
DS RISalud
RD Apr 6, 2025