RT Journal Article
T1 Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study.
A1 Sieri, Sabina
A1 Agnoli, Claudia
A1 Grioni, Sara
A1 Weiderpass, Elisabete
A1 Mattiello, Amalia
A1 Sluijs, Ivonne
A1 Sanchez-Perez, Maria-Jose
A1 Jakobsen, Marianne Uhre
A1 Sweeting, Michael
A1 van der Schouw, Yvonne T
A1 Nilsson, Lena Maria
A1 Wennberg, Patrik
A1 Katzke, Verena A
A1 Kühn, Tilman
A1 Overvad, Kim
A1 Tong, Tammy Y N
A1 Conchi, Moreno-Iribas
A1 Quirós, José Ramón
A1 García-Torrecillas, Juan Manuel
A1 Mokoroa, Olatz
A1 Gómez, Jesús-Humberto
A1 Tjønneland, Anne
A1 Sonestedt, Emiliy
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Valanou, Elissavet
A1 Boer, Jolanda M A
A1 Verschuren, W M Monique
A1 Boutron-Ruault, Marie-Christine
A1 Fagherazzi, Guy
A1 Madika, Anne-Laure
A1 Bergmann, Manuela M
A1 Schulze, Matthias B
A1 Ferrari, Pietro
A1 Freisling, Heinz
A1 Lennon, Hannah
A1 Sacerdote, Carlotta
A1 Masala, Giovanna
A1 Tumino, Rosario
A1 Riboli, Elio
A1 Wareham, Nicholas J
A1 Danesh, John
A1 Forouhi, Nita G
A1 Butterworth, Adam S
A1 Krogh, Vittorio
K1 EPIC study
K1 EPIC-CVD study
K1 cohort study
K1 coronary heart disease
K1 glycemic index
K1 glycemic load
AB High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) ≥25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI  This large pan-European study provides robust additional support for the hypothesis that a diet that induces a high glucose response is associated with greater CHD risk.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/15869
UL http://hdl.handle.net/10668/15869
LA en
DS RISalud
RD Apr 11, 2025