RT Journal Article
T1 Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease.
A1 Pineda, Carmen
A1 Aguilera-Tejero, Escolastico
A1 Morales, Maria C
A1 Belinchon-Lorenzo, Silvia
A1 Gomez-Nieto, Luis C
A1 Garcia, Pablo
A1 Martinez-Moreno, Julio M
A1 Rodriguez-Ortiz, Maria E
A1 Lopez, Ignacio
K1 Kidney Function Tests
K1 Leishmaniasis
K1 Male
K1 Parasite Load
K1 Real-Time Polymerase Chain Reaction
AB Treatment of canine leishmaniasis (CanL) represents a challenge. Due to the high prevalence of renal disease associated to CanL, it is important to find an effective drug that does not damage the kidneys. Marbofloxacin has been shown to be effective and well tolerated in non-azotemic dogs with leishmaniasis. To evaluate the safety and efficacy of marbofloxacin in dogs with leishmaniasis and decreased renal function, 28 dogs suffering from leishmaniasis and chronic kidney disease (CKD) were treated with oral marbofloxacin at 2 mg/Kg/day for 28 days. During treatment dogs were assessed by performing weekly physical exams, measuring blood pressure and evaluating blood and urine parameters. Lymph node aspirations were also obtained at days 0 and 28. The global clinical score decreased significantly, from 6.2±3.4 to 4.7±3.1 (p = 0.0001), after treatment. Marbofloxacin also decreased parasitic load in 72% of the dogs. No significant differences in plasma creatinine, urine specific gravity, urinary concentrations of cystatin C, ferritin and urinary protein loss were detected during treatment. A transient but significant decrease in blood pressure was detected up to day 14 (from 180.1±36.6 to 166.0±32.7 mmHg; p = 0.016). Moreover, dogs showed a significant increase in plasma albumin concentration (from 15.0±5.2 to 16.6±3.9 g/L; p = 0.014) and a significant decrease in globulin concentration (from 59.0±18.1 to 54.1±18.0 g/L; p = 0.005). The results demonstrate that, in addition to being effective for treatment of CanL, marbofloxacin is a very safe drug in dogs with CKD and leishmaniasis.
PB Public Library of Science
YR 2017
FD 2017-09-22
LK http://hdl.handle.net/10668/11651
UL http://hdl.handle.net/10668/11651
LA en
NO Pineda C, Aguilera-Tejero E, Morales MC, Belinchon-Lorenzo S, Gomez-Nieto LC, Garcia P, et al. Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease. PLoS One. 2017 Oct 5;12(10):e0185981
DS RISalud
RD Apr 17, 2025