RT Journal Article
T1 Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease.
A1 López-Jiménez, Elena
A1 González-Aguilera, Cristina
K1 cell identity
K1 chromatin organization
K1 chromatin replication
K1 epigenetic maintenance
K1 parental histone recycling
K1 transcription regulation
AB Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer.
YR 2022
FD 2022-06-02
LK http://hdl.handle.net/10668/20977
UL http://hdl.handle.net/10668/20977
LA en
DS RISalud
RD Apr 8, 2025