%0 Journal Article
%A López-Jiménez, Elena
%A González-Aguilera, Cristina
%T Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease.
%D 2022
%U http://hdl.handle.net/10668/20977
%X Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer.
%K cell identity
%K chromatin organization
%K chromatin replication
%K epigenetic maintenance
%K parental histone recycling
%K transcription regulation
%~