RT Journal Article
T1 Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey.
A1 Lytras, Theodore
A1 Kogevinas, Manolis
A1 Kromhout, Hans
A1 Carsin, Anne-Elie
A1 Antó, Josep M
A1 Bentouhami, Hayat
A1 Weyler, Joost
A1 Heinrich, Joachim
A1 Nowak, Dennis
A1 Urrutia, Isabel
A1 Martinez-Moratalla, Jesús
A1 Gullón, José Antonio
A1 Pereira-Vega, Antonio
A1 Raherison-Semjen, Chantal
A1 Pin, Isabelle
A1 Demoly, Pascal
A1 Leynaert, Bénédicte
A1 Villani, Simona
A1 Gislason, Thorarinn
A1 Svanes, Cecilie
A1 Holm, Mathias
A1 Forsberg, Bertil
A1 Norbäck, Dan
A1 Mehta, Amar J
A1 Probst-Hensch, Nicole
A1 Benke, Geza
A1 Jogi, Rain
A1 Torén, Kjell
A1 Sigsgaard, Torben
A1 Schlünssen, Vivi
A1 Olivieri, Mario
A1 Blanc, Paul D
A1 Vermeulen, Roel
A1 Garcia-Aymerich, Judith
A1 Jarvis, Deborah
A1 Zock, Jan-Paul
K1 copd epidemiology
K1 occupational lung disease
AB Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using postbronchodilator lung function tests. Our objective was to examine the effect of occupational exposures on COPD incidence in the European Community Respiratory Health Survey. General population samples aged 20-44 were randomly selected in 1991-1993 and followed up 20 years later (2010-2012). Spirometry was performed at baseline and at follow-up, with incident COPD defined using a lower limit of normal criterion for postbronchodilator FEV1/FVC. Only participants without COPD and without current asthma at baseline were included. Coded job histories during follow-up were linked to a Job-Exposure Matrix, generating occupational exposure estimates to 12 categories of agents. Their association with COPD incidence was examined in log-binomial models fitted in a Bayesian framework. 3343 participants fulfilled the inclusion criteria; 89 of them had COPD at follow-up (1.4 cases/1000 person-years). Participants exposed to biological dust had a higher incidence of COPD compared with those unexposed (relative risk (RR) 1.6, 95% CI 1.1 to 2.3), as did those exposed to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%. These results substantially strengthen the evidence base for occupational exposures as an important risk factor for COPD.
YR 2018
FD 2018-03-24
LK http://hdl.handle.net/10668/12273
UL http://hdl.handle.net/10668/12273
LA en
DS RISalud
RD Apr 17, 2025