RT Journal Article
T1 In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells.
A1 Palmquist-Gomes, Paul
A1 Marín-Sedeño, Ernesto
A1 Ruiz-Villalba, Adrián
A1 Rico-Llanos, Gustavo Adolfo
A1 Pérez-Pomares, José María
A1 Guadix, Juan Antonio
K1 avian embryo
K1 cardiac regeneration
K1 cartilage
K1 chondrocytes
K1 differentiation
K1 epicardial-derived cells
K1 epicardium
K1 proepicardium
K1 quail to chick chimeras
AB The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli.
YR 2022
FD 2022-03-25
LK http://hdl.handle.net/10668/21145
UL http://hdl.handle.net/10668/21145
LA en
DS RISalud
RD Apr 8, 2025