TY - JOUR AU - Cobo-Vuilleumier, Nadia AU - Lorenzo, Petra I. AU - García Rodríguez, Noelia AU - Herrera Gómez, Irene de Gracia AU - Fuente-Martin, Esther AU - López-Noriega, Livia AU - Mellado-Gil, José Manuel AU - Romero-Zerbo, Silvana-Yanina AU - Baquié, Mathurin AU - Lachaud, Christian Claude AU - Stifter, Katja AU - German, Perdomo AU - Marco, Bugliani AU - De Tata, Vincenzo AU - Bosco, Domenico AU - Parnaud, Geraldine AU - Pozo, David AU - Hmadcha, Abdelkrim AU - Florido, Javier P. AU - Toscano, Miguel G. AU - de Haan, Peter AU - Schoonjans, Kristina AU - Sánchez Palazón, Luis AU - Marchetti, Piero AU - Schirmbeck, Reinhold AU - Martín-Montalvo, Alejandro AU - Meda, Paolo AU - Soria, Bernat AU - Bermúdez-Silva, Francisco-Javier AU - St-Onge, Luc AU - Gauthier, Benoit R. PY - 2018 DO - 10.1038/s41467-018-03943-0 UR - http://hdl.handle.net/10668/2858 T2 - Nature Communications AB - Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore,... LA - en PB - Springer Nature KW - Islets of Langerhans KW - Type 1 diabetes KW - Type 2 diabetes KW - Islotes Pancreáticos KW - Diabetes Mellitus Tipo 1 KW - Diabetes Mellitus Tipo 2 KW - Diabetes Mellitus KW - Diabetes KW - Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 1 KW - Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 KW - Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Islets of Langerhans KW - Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae KW - Medical Subject Headings::Organisms::Eukaryota::Animals TI - LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus TY - research article ER -