RT Journal Article
T1 LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
A1 Cobo-Vuilleumier, Nadia
A1 Lorenzo, Petra I.
A1 García Rodríguez, Noelia
A1 Herrera Gómez, Irene de Gracia
A1 Fuente-Martin, Esther
A1 López-Noriega, Livia
A1 Mellado-Gil, José Manuel
A1 Romero-Zerbo, Silvana-Yanina
A1 Baquié, Mathurin
A1 Lachaud, Christian Claude
A1 Stifter, Katja
A1 German, Perdomo
A1 Marco, Bugliani
A1 De Tata, Vincenzo
A1 Bosco, Domenico
A1 Parnaud, Geraldine
A1 Pozo, David
A1 Hmadcha, Abdelkrim
A1 Florido, Javier P.
A1 Toscano, Miguel G.
A1 de Haan, Peter
A1 Schoonjans, Kristina
A1 Sánchez Palazón, Luis
A1 Marchetti, Piero
A1 Schirmbeck, Reinhold
A1 Martín-Montalvo, Alejandro
A1 Meda, Paolo
A1 Soria, Bernat
A1 Bermúdez-Silva, Francisco-Javier
A1 St-Onge, Luc
A1 Gauthier, Benoit R.
K1 Islets of Langerhans
K1 Type 1 diabetes
K1 Type 2 diabetes
K1 Islotes Pancreáticos
K1 Diabetes Mellitus Tipo 1
K1 Diabetes Mellitus Tipo 2
K1 Diabetes Mellitus
K1 Diabetes
AB Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus.
PB Springer Nature
YR 2018
FD 2018-04-16
LK http://hdl.handle.net/10668/2858
UL http://hdl.handle.net/10668/2858
LA en
NO Cobo-Vuilleumier, N; Lorenzo, PI; García Rodríguez, N; Herrera Gómez, IG; Fuente-Martin, E; López-Noriega, L, et al. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nature Communications. 2018;9(1):1488
DS RISalud
RD Apr 8, 2025