RT Journal Article
T1 Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders.
A1 Flores-López, María
A1 García-Marchena, Nuria
A1 Araos, Pedro
A1 Requena-Ocaña, Nerea
A1 Porras-Perales, Oscar
A1 Torres-Galván, Sandra
A1 Suarez, Juan
A1 Pizarro, Nieves
A1 de la Torre, Rafael
A1 Rubio, Gabriel
A1 Ruiz-Ruiz, Juan Jesús
A1 Rodríguez de Fonseca, Fernando
A1 Serrano, Antonia
A1 Pavón-Morón, Francisco Javier
K1 alcohol
K1 biomarker
K1 cocaine
K1 lysophosphatidic acid
K1 sex
K1 substance use disorder
AB Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.
SN 2076-3425
YR 2022
FD 2022-04-30
LK http://hdl.handle.net/10668/20854
UL http://hdl.handle.net/10668/20854
LA en
DS RISalud
RD Apr 9, 2025