RT Journal Article
T1 Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration.
A1 García-Revilla, Juan
A1 Boza-Serrano, Antonio
A1 Espinosa-Oliva, Ana M
A1 Soto, Manuel Sarmiento
A1 Deierborg, Tomas
A1 Ruiz, Rocío
A1 de Pablos, Rocío M
A1 Burguillos, Miguel Angel
A1 Venero, Jose L
AB The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.
YR 2022
FD 2022-07-20
LK http://hdl.handle.net/10668/19529
UL http://hdl.handle.net/10668/19529
LA en
DS RISalud
RD Apr 6, 2025