RT Journal Article
T1 Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer.
A1 Marrero, Ana Dácil
A1 Quesada, Ana R
A1 Martínez-Poveda, Beatriz
A1 Medina, Miguel Ángel
K1 angiogenesis
K1 bioactive compounds
K1 cancer prevention
K1 chemoprevention
K1 phytochemicals
AB Despite the extensive knowledge on cancer nature acquired over the last years, the high incidence of this disease evidences a need for new approaches that complement the clinical intervention of tumors. Interestingly, many types of cancer are closely related to dietary habits associated with the Western lifestyle, such as low fruit and vegetable intake. Recent advances around the old-conceived term of chemoprevention highlight the important role of phytochemicals as good candidates for the prevention or treatment of cancer. The potential to inhibit angiogenesis exhibited by many natural compounds constituent of plant foods makes them especially interesting for their use as chemopreventive agents. Here, we review the antitumoral potential, with a focus on the antiangiogenic effects, of phenolic and polyphenolic compounds, such as quercetin or myricetin; terpenoids, such as ursolic acid or kahweol; and anthraquinones from Aloe vera, in different in vitro and in vivo assays, and the available clinical data. Although clinical trials have failed to assess the preventive role of many of these compounds, encouraging preclinical data support the efficacy of phytochemicals constituent of diet in the prevention and treatment of cancer, but a deeper understanding of their mechanisms of action and better designed clinical trials are urgently needed.
SN 2076-3921
YR 2022
FD 2022-01-31
LK http://hdl.handle.net/10668/20773
UL http://hdl.handle.net/10668/20773
LA en
DS RISalud
RD Apr 11, 2025