RT Journal Article
T1 Distribution and Outcomes of a Phenotype-Based Approach to Guide COPD Management: Results from the CHAIN Cohort.
A1 Cosio, Borja G
A1 Soriano, Joan B
A1 López-Campos, Jose Luis
A1 Calle, Myriam
A1 Soler, Juan José
A1 de-Torres, Juan Pablo
A1 Marín, Jose Maria
A1 Martínez, Cristina
A1 de Lucas, Pilar
A1 Mir, Isabel
A1 Peces-Barba, Germán
A1 Feu-Collado, Nuria
A1 Solanes, Ingrid
A1 Alfageme, Inmaculada
A1 CHAIN study, 
AB The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes. We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes. Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19 (2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV1 and BODE index (all p There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use.
YR 2016
FD 2016-09-29
LK https://hdl.handle.net/10668/27186
UL https://hdl.handle.net/10668/27186
LA en
DS RISalud
RD Apr 11, 2025