RT Journal Article
T1 Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies.
A1 Jayasekara, Harindra
A1 MacInnis, Robert J
A1 Lujan-Barroso, Leila
A1 Mayen-Chacon, Ana-Lucia
A1 Cross, Amanda J
A1 Wallner, Bengt
A1 Palli, Domenico
A1 Ricceri, Fulvio
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Tsilidis, Kostas
A1 Sanchez-Perez, Maria-Jose
A1 Amiano, Pilar
A1 Ardanaz, Eva
A1 Chirlaque López, María Dolores
A1 Merino, Susana
A1 Rothwell, Joseph A
A1 Boutron-Ruault, Marie-Christine
A1 Severi, Gianluca
A1 Sternby, Hanna
A1 Sonestedt, Emily
A1 Bueno-de-Mesquita, Bas
A1 Boeing, Heiner
A1 Travis, Ruth
A1 Sandanger, Torkjel M
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Peppa, Eleni
A1 Tjønneland, Anne
A1 Yang, Yi
A1 Hodge, Allison M
A1 Mitchell, Hazel
A1 Haydon, Andrew
A1 Room, Robin
A1 Hopper, John L
A1 Weiderpass, Elisabete
A1 Gunter, Marc J
A1 Riboli, Elio
A1 Giles, Graham G
A1 Milne, Roger L
A1 Agudo, Antonio
A1 English, Dallas R
A1 Ferrari, Pietro
K1 EPIC
K1 MCCS
K1 cardia cancer
K1 lifetime alcohol intake
K1 noncardia cancer
K1 stomach cancer
AB Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
YR 2021
FD 2021-02-22
LK http://hdl.handle.net/10668/17120
UL http://hdl.handle.net/10668/17120
LA en
DS RISalud
RD Apr 9, 2025