RT Generic
T1 Combination therapy for bloodstream infections with carbapenemase-producing Enterobacteriaceae - Authors' reply.
A1 Gutierrez-Gutierrez, Belen
A1 Bonomo, Robert A
A1 Carmeli, Yehuda
A1 Paterson, David L
A1 Pascual, Alvaro
A1 Rodriguez-Baño, Jesus
K1 Anti-Bacterial Agents
K1 Bacterial Proteins
K1 Enterobacteriaceae
K1 Humans
K1 beta-Lactamases
AB We thank Bernd Salzberger and Gerd Fätkenheuer for their interest in our study.1 They were concerned about the use of Charlson, Pitt, and INCREMENT-CPE scores, as well as the individual variables contained in them in the analyses. Our objective was to provide the best possible estimation of the association of the main exposure ( treatment ) with the outcome considering the effect of confounders, in accordance with the study hypothesis; we did not intend to provide a model to predict outcome ( mortality ). Therefore, we did several multivariate analyses , including models with the individual variables, models with the scores, and models with both, after checking for collinearity. The best models were selected and are shown in tables 2 and 3 of our paper .1 As a result, when the scores were considered, the individual variables were not relevant and the effect of treatment on mortality was adjusted by the scores.
PB The Lancet Publishing Group
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11609
UL http://hdl.handle.net/10668/11609
LA en
NO Gutiérrez-Gutiérrez B, Bonomo RA, Carmeli Y, Paterson DL, Pascual A, Rodríguez-Baño J. Combination therapy for bloodstream infections with carbapenemase-producing Enterobacteriaceae - Authors' reply. Lancet Infect Dis. 2017 Oct;17(10):1020-1021.
DS RISalud
RD Apr 8, 2025