RT Journal Article
T1 A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.
A1 Gutman, Boris A
A1 van Erp, Theo G M
A1 Alpert, Kathryn
A1 Ching, Christopher R K
A1 Isaev, Dmitry
A1 Ragothaman, Anjani
A1 Jahanshad, Neda
A1 Saremi, Arvin
A1 Zavaliangos-Petropulu, Artemis
A1 Glahn, David C
A1 Shen, Li
A1 Cong, Shan
A1 Alnaes, Dag
A1 Andreassen, Ole Andreas
A1 Doan, Nhat Trung
A1 Westlye, Lars T
A1 Kochunov, Peter
A1 Satterthwaite, Theodore D
A1 Wolf, Daniel H
A1 Huang, Alexander J
A1 Kessler, Charles
A1 Weideman, Andrea
A1 Nguyen, Dana
A1 Mueller, Bryon A
A1 Faziola, Lawrence
A1 Potkin, Steven G
A1 Preda, Adrian
A1 Mathalon, Daniel H
A1 Bustillo, Juan
A1 Calhoun, Vince
A1 Ford, Judith M
A1 Walton, Esther
A1 Ehrlich, Stefan
A1 Ducci, Giuseppe
A1 Banaj, Nerisa
A1 Piras, Fabrizio
A1 Piras, Federica
A1 Spalletta, Gianfranco
A1 Canales-Rodriguez, Erick J
A1 Fuentes-Claramonte, Paola
A1 Pomarol-Clotet, Edith
A1 Radua, Joaquim
A1 Salvador, Raymond
A1 Sarró, Salvador
A1 Dickie, Erin W
A1 Voineskos, Aristotle
A1 Tordesillas-Gutierrez, Diana
A1 Crespo-Facorro, Benedicto
A1 Setien-Suero, Esther
A1 Mayoral-van-Son, Jacqueline
A1 Borgwardt, Stefan
A1 Schönborn-Harrisberger, Fabienne
A1 Morris, Derek
A1 Donohoe, Gary
A1 Holleran, Laurena
A1 Cannon, Dara
A1 McDonald, Colm
A1 Corvin, Aiden
A1 Gill, Michael
A1 Filho, Geraldo Busatto
A1 Rosa, Pedro G P
A1 Serpa, Mauricio H
A1 Zanetti, Marcus V
A1 Lebedeva, Irina
A1 Kaleda, Vasily
A1 Tomyshev, Alexander
A1 Crow, Tim
A1 James, Anthony
A1 Cervenka, Simon
A1 Sellgren, Carl M
A1 Fatouros-Bergman, Helena
A1 Agartz, Ingrid
A1 Howells, Fleur
A1 Stein, Dan J
A1 Temmingh, Henk
A1 Uhlmann, Anne
A1 de Zubicaray, Greig I
A1 McMahon, Katie L
A1 Wright, Margie
A1 Cobia, Derin
A1 Csernansky, John G
A1 Thompson, Paul M
A1 Turner, Jessica A
A1 Wang, Lei
K1 schizophrenia
K1 structure
K1 subcortical shape
AB Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
PB John Wiley & Sons, Inc.
YR 2021
FD 2021-12-16
LK http://hdl.handle.net/10668/18501
UL http://hdl.handle.net/10668/18501
LA en
NO Gutman BA, van Erp TGM, Alpert K, Ching CRK, Isaev D, Ragothaman A, et al. A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium. Hum Brain Mapp. 2022 Jan;43(1):352-372.
DS RISalud
RD Apr 17, 2025