RT Journal Article
T1 Survival After Lung Transplantation for Chronic Hypersensitivity Pneumonitis: Results From a Large International Cohort Study.
A1 Nosotti, Mario
A1 Leiva-Juarez, Miguel
A1 D'Ovidio, Frank
A1 Van Raemdonck, Dirk
A1 Ceulemans, Laurens
A1 Keshavjee, Shaf
A1 Rackauskas, Mindaugas
A1 Paladini, Piero
A1 Luzzi, Luca
A1 Casado, Paula Moreno
A1 Alvarez, Antonio
A1 Inci, Ilhan
A1 Ehrsam, Jonas
A1 Krueger, Thorsten
A1 Roth, Andrey
A1 Rea, Federico
A1 Schiavon, Marco
A1 Rosso, Lorenzo
K1 hypersensitivity pneumonitis
K1 interstitial pneumonia
K1 lung transplant
K1 pneumonia
K1 rare lung disease
K1 respiratory insufficiency
AB Repeated exposure to antigens via inhalation is the primary cause of hypersensitivity pneumonitis, a form of interstitial pneumonia. The chronic form of hypersensitivity pneumonitis leads to progressive loss of respiratory function; lung transplantation is the only therapeutic option for chronically ill patients. The ESTS Lung Transplantation Working Group conducted a retrospective multicentred cohort study to increase the body of knowledge available on this rare indication for lung transplantation. Data were collected for every patient who underwent lung transplant for hypersensitivity pneumonitis in participating centres between December 1996 and October 2019. Primary outcome was overall survival; secondary outcome was freedom from chronic lung allograft dysfunction. A total of 114 patients were enrolled from 9 centres. Almost 90% of patients were diagnosed with hypersensitivity pneumonitis before transplantation, yet the antigen responsible for the infection was identified in only 25% of cases. Eighty per cent of the recipients received induction therapy. Survival at 1, 3, and 5 years was 85%, 75%, and 70%, respectively. 85% of the patients who survived 90 days after transplantation were free from chronic lung allograft dysfunction after 3 years. The given study presents a large cohort of HP patients who underwent lung transplants. Overall survival rate is higher in transplanted hypersensitivity pneumonitis patients than in those suffering from any other interstitial lung diseases. Hypersensitivity pneumonitis patients are good candidates for lung transplantation.
YR 2022
FD 2022-03-31
LK http://hdl.handle.net/10668/20755
UL http://hdl.handle.net/10668/20755
LA en
DS RISalud
RD Apr 17, 2025