RT Journal Article
T1 Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus
A1 Hiraldo-González, Laura
A1 Trillo-Contreras, José Luis
A1 García-Miranda, Pablo
A1 Pineda-Sánchez, Rocío
A1 Ramírez-Lorca, Reposo
A1 Rodrigo-Herrero, Silvia
A1 Blanco, Magdalena Olivares
A1 Oliver, María
A1 Bernal, Maria
A1 Franco-Macías, Emilio
A1 Villadiego, Javier
A1 Echevarría, Miriam
K1 Aquaporins
K1 Cerebrospinal fluid
K1 Hydrocephalus, normal pressure
K1 Alzheimer disease
K1 Diagnosis
K1 Acuaporinas
K1 Líquido cefalorraquídeo
K1 Hidrocéfalo normotenso
K1 Enfermedad de Alzheimer
K1 Diagnóstico
AB Brain aquaporin 1 (AQP1) and AQP4 are involved in cerebrospinal fluid (CSF) homeostasis and might participate in the origin of hydrocephalus. Studies have shown alterations of perivascular AQP4 expression in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD). Due to the overlapping of clinical signs between iNPH and certain neurological conditions, mainly AD, specific biomarkers might improve the diagnostic accuracy for iNPH. The goal of the present study was to analyze and quantify the presence of AQP1 and AQP4 in the CSF of patients with iNPH and AD to determine whether these proteins can be used as biomarkers of iNPH. We examined AQP1 and AQP4 protein levels in the CSF of 179 participants (88 women) classified into 5 groups: possible iNPH (81 participants), hydrocephalus associated with other neurological disorders (13 participants), AD (41 participants), non-AD dementia (32 participants) and healthy controls (12 participants). We recorded each participant's demographic and clinical variables and indicated, when available in the clinical history, the record of cardiovascular and respiratory complications. An ELISA showed virtually no AQP content in the CSF. Information on the vascular risk factors (available for 61 patients) confirmed some type of vascular risk factor in 86% of the patients with possible iNPH and 58% of the patients with AD. In conclusion, the ELISA analysis showed insufficient sensitivity to detect the presence of AQP1 and AQP4 in CSF, ruling out the possible use of these proteins as biomarkers for diagnosing iNPH.
PB Public Library of Science
YR 2021
FD 2021-10-01
LK http://hdl.handle.net/10668/4496
UL http://hdl.handle.net/10668/4496
LA en
NO Hiraldo-González L, Trillo-Contreras JL, García-Miranda P, Pineda-Sánchez R, Ramírez-Lorca R, Rodrigo-Herrero S, et al. Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus. PLoS One. 2021 Oct 1;16(10):e0258165
DS RISalud
RD Apr 5, 2025