TY - JOUR AU - Santamaria, Rafael AU - Diaz-Tocados, Juan M AU - Pendon-Ruiz de Mier, M Victoria AU - Robles, Ana AU - Salmeron-Rodriguez, M Dolores AU - Ruiz, Erena AU - Vergara, Noemi AU - Aguilera-Tejero, Escolastico AU - Raya, Ana AU - Ortega, Rosa AU - Felsenfeld, Arnold AU - Muñoz-Castañeda, Juan R AU - Marin-Malo, Alejandro AU - Aljama, Pedro AU - Rodriguez, Mariano PY - 2018 DO - 10.1038/s41598-018-32065-2 UR - http://hdl.handle.net/10668/12939 T2 - Scientific reports AB - In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of... LA - en PB - Nature Publishing Group KW - Proteinuria KW - Rats, Zucker KW - Reactive Oxygen Species KW - Renal Insufficiency, Chronic KW - Young Adult KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Animals KW - Antioxidants KW - Cell Line KW - Female KW - Glomerular Filtration Rate KW - Glucuronidase KW - HEK293 Cells KW - Humans KW - Hyperphosphatemia KW - Hypophosphatemia, Familial KW - Kidney KW - Klotho Proteins KW - Male KW - Melatonin KW - Metabolic Syndrome KW - Middle Aged KW - Oxidative Stress KW - Phosphates TI - Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms. TY - research article VL - 8 ER -