RT Generic
T1 STIM and Orail Variants in Store-Operated Calcium Entry
A1 Rosado, Juan A.
A1 Diez, Raquel
A1 Smani, Tarik
A1 Jardin, Isaac
K1 calcium entry
K1 STIM1
K1 STIM2
K1 orail
K1 splice variants
K1 Stromal interaction molecule-1
K1 Alternative translation initiation
K1 Activates crac channels
K1 Ca2+ entry
K1 Trpc channels
K1 Mechanistic insights
K1 Arc channel
K1 Sam domain
K1 C-terminus
K1 I-crac
AB Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the Stromal Interaction Molecule (STIM) family, STIM1, and STIM2. Store-dependent, STIM1-modulated, channels include the Ca2+ release-activated Ca2+ channels, comprised of subunits of Orai proteins, as well as the store-operated Ca2+ (SOC) channels, involving Orai1, and members of the canonical transient receptor potential family of proteins. Recent studies have revealed the expression of splice variants of STIM1, STIM2, and Orai1 in different cell types. While certain variants are ubiquitously expressed, others, such as STIM1L, show a more restricted expression. The splice variants for STIM and Orai1 proteins exhibit significant functional differences and reveal that alternative splicing enhance the functional diversity of STIM1, STIM2, and Orai1 genes to modulate the dynamics of Ca2+ signals.
PB Frontiers media sa
SN 1663-9812
YR 2016
FD 2016-01-13
LK http://hdl.handle.net/10668/19238
UL http://hdl.handle.net/10668/19238
LA en
DS RISalud
RD Apr 11, 2025