RT Journal Article
T1 Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
A1 Benavente, Cristina
A1 León, Josefa
A1 Feriche, Belén
A1 Schoenfeld, Brad J.
A1 Bonitch-Góngora, Juan
A1 Almeida, Filipa
A1 Pérez-Regalado, Sergio
A1 Padial, Paulino
K1 Strength
K1 Cytokines
K1 miRNA
K1 Terrestrial altitude
K1 Hypoxia
K1 Entrenamiento de fuerza
K1 Citocinas
K1 MicroARNs
K1 Hipoxia
AB This study investigated the effect of a traditional hypertrophy-oriented resistance training (RT) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic RT session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNFα), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the RT session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = -0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a RT session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated.
PB MDPI AG
SN 1661-7827
YR 2021
FD 2021-04-16
LK http://hdl.handle.net/10668/3466
UL http://hdl.handle.net/10668/3466
LA en
NO Benavente C, León J, Feriche B, Schoenfeld BJ, Bonitch-Góngora J, Almeida F, et al. Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude. International Journal of Environmental Research and Public Health. 2021;18(8):4233.
DS RISalud
RD Apr 8, 2025