%0 Journal Article
%A Benavente, Cristina
%A León, Josefa
%A Feriche, Belén
%A Schoenfeld, Brad J.
%A Bonitch-Góngora, Juan
%A Almeida, Filipa
%A Pérez-Regalado, Sergio
%A Padial, Paulino
%T Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
%D 2021
%@ 1661-7827
%U http://hdl.handle.net/10668/3466
%X This study investigated the effect of a traditional hypertrophy-oriented resistance training (RT) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic RT session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNFα), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the RT session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = -0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a RT session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated.
%K Strength
%K Cytokines
%K miRNA
%K Terrestrial altitude
%K Hypoxia
%K Entrenamiento de fuerza
%K Citocinas
%K MicroARNs
%K Hipoxia
%~