TY - JOUR AU - Sanchez-Mejias, Elisabeth AU - Navarro, Victoria AU - Jimenez, Sebastian AU - Sanchez-Mico, Maria AU - Sanchez-Varo, Raquel AU - Nuñez-Diaz, Cristina AU - Trujillo-Estrada, Laura AU - Davila, Jose Carlos AU - Vizuete, Marisa AU - Gutierrez, Antonia AU - Vitorica, Javier PY - 2016 DO - 10.1007/s00401-016-1630-5 UR - http://hdl.handle.net/10668/10537 T2 - Acta neuropathologica AB - The role of microglial cells in the development and progression of Alzheimer's disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in contrast to the massive... LA - en KW - Alzheimer KW - Hippocampus KW - Human brain KW - Microglia KW - Pathology KW - Adult KW - Aged KW - Aged, 80 and over KW - Alzheimer Disease KW - Amyloid beta-Protein Precursor KW - Animals KW - Antigens, CD KW - Antigens, Differentiation, Myelomonocytic KW - Apoptosis KW - Calcium-Binding Proteins KW - Cells, Cultured KW - DNA-Binding Proteins KW - Disease Progression KW - Female KW - Gene Expression Regulation KW - Hippocampus KW - Humans KW - Leukocyte Common Antigens KW - Male KW - Mice KW - Mice, Transgenic KW - Microfilament Proteins KW - Microglia KW - Middle Aged KW - Presenilin-1 KW - Receptors, Purinergic P2Y12 KW - tau Proteins TI - Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration. TY - research article VL - 132 ER -