RT Journal Article
T1 Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence.
A1 Del-Valle-Ramirez, Karla
A1 Fernandez, Rosa
A1 Delgado-Zayas, Enrique
A1 Gomez-Gil, Esther
A1 Esteva, Isabel
A1 Guillamon, Antonio
A1 Pasaro, Eduardo
K1 Estrogen Coactivators
K1 Estrogens
K1 Gender Dysphoria
K1 Gender Incongruence
K1 SRC-1
K1 SRC-2
K1 SRC-3
AB Brain sexual differentiation results from the effects of sex steroids on the developing brain. The presumptive route for brain masculinization is the direct induction of gene expression via activation of the estrogen receptors α and β and the androgen receptor through their binding to ligands and to coactivators, regulating the transcription of multiple genes in a cascade effect. To analyze the implication of the estrogen receptor coactivators SRC-1, SRC-2, and SRC-3 in the genetic basis of gender incongruence. Analysis of 157 polymorphisms located at the estrogen receptor coactivators SRC-1, SRC-2, and SRC-3, in 94 transgender versus 94 cisgender individuals. Using SNPStats software, the allele and genotype frequencies were analyzed by χ2, the strength of the association was measured by binary logistic regression, estimating the odds ratio for each genotype. Measurements of linkage disequilibrium and haplotype frequencies were also performed. We found significant differences at level P  The coactivators SRC-1 and SRC-2 could be considered as candidates for increasing the list of potential genes for gender incongruence. Ramírez KDV, Fernández R, Delgado-Zayas E, et al. Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence. Sex Med 2021;9:100368.
PB Oxford University Press
SN 2050-1161
YR 2021
FD 2021-03-30
LK http://hdl.handle.net/10668/17848
UL http://hdl.handle.net/10668/17848
LA en
NO Ramírez KDV, Fernández R, Delgado-Zayas E, Gómez-Gil E, Esteva I, Guillamon A, et al. Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence. Sex Med. 2021 Jun;9(3):100368
DS RISalud
RD Apr 19, 2025