RT Conference Proceedings
T1 UNSUPERVISED CLUSTERING ANALYSIS OF THE SERUM PROTEOME IDENTIFIES SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH DISTINCTIVE DISEASE SEVERITY AND LUPUS NEPHROPATHY
A1 Lopez-Pedrera, C.
A1 Aguirre-Zamorano, M. A.
A1 Munoz-Barrera, L.
A1 Sanchez-Pareja, I.
A1 Pilar, F. U.
A1 Abalos-Aguilera, M. C.
A1 Puerto, N. Barbarroja
A1 Estevez, E. Collantes
A1 Castro, R. Ortega
A1 Perez-Sanchez, C.
K1 Pisum sativum
K1 Proteomics
K1 Lupus Erythematosus, Systemic
AB Background: Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite great efforts, our knowledge of serum proteinpatterns in severe SLE phenotypes is still limited.Objectives: This study investigated the serum proteomic profile of SLE, in orderto identify relevant clinical patterns.Methods: Proximity extension immunoassay (PEA, Olink) was used toassess the serum levels of one hundred and eighty-four inflammation andorgan damage-related proteins in patients with SLE (n = 72) and agematched healthy donors (HD) (n = 18). In parallel, an extensive clinical andanalytical profile of recruited subjects was performed. To evaluate the contribution of molecular profiles to the disease severity, unsupervised clustering analyses were developed.
PB BMJ Group
SN 0003-4967
YR 2022
FD 2022-06-01
LK http://hdl.handle.net/10668/20118
UL http://hdl.handle.net/10668/20118
LA en
NO Lopez-Pedrera C, Aguirre-Zamorano MÁ, Muñoz-Barrera L, Sanchez-Pareja I, Pilar FU, Ábalos-Aguilera MC, et al. POS0465 UNSUPERVISED CLUSTERING ANALYSIS OF THE SERUM PROTEOME IDENTIFIES SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH DISTINCTIVE DISEASE SEVERITY AND LUPUS NEPHROPATHY. Annals Of The Rheumatic Diseases [Internet]. 23 de mayo de 2022;81(Suppl 1):486.2-487
DS RISalud
RD Apr 8, 2025