RT Journal Article
T1 Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider.
A1 Garcia-Revilla, Juan
A1 Deierborg, Tomas
A1 Venero, Jose Luis
A1 Boza-Serrano, Antonio
K1 COVID-19
K1 biomarker
K1 cytokine storm
K1 fibrosis
K1 galectin-3
AB COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.
YR 2020
FD 2020-08-18
LK http://hdl.handle.net/10668/16312
UL http://hdl.handle.net/10668/16312
LA en
DS RISalud
RD Apr 7, 2025