RT Journal Article
T1 Antiretroviral therapy partially improves the abnormalities of dendritic cells and lymphoid and myeloid regulatory populations in recently infected HIV patients.
A1 Marquez-Coello, Mercedes
A1 Montes de Oca Arjona, Montserrat
A1 Martin-Aspas, Andres
A1 Guerrero Sanchez, Francisca
A1 Fernandez-Gutierrez Del Alamo, Clotilde
A1 Giron-Gonzalez, Jose A
K1 Anti-HIV Agents
K1 Blood Cell Count
K1 Dendritic Cells
K1 Female
K1 HIV Infections
K1 HIV-1
AB This study aimed to evaluate the effects of antiretroviral therapy on plasmacytoid (pDC) and myeloid (mDC) dendritic cells as well as regulatory T (Treg) and myeloid-derived suppressor (MDSC) cells in HIV-infected patients. Forty-five HIV-infected patients (20 of them with detectable HIV load -10 recently infected and 10 chronically infected patients-, at baseline and after antiretroviral therapy, and 25 with undetectable viral loads) and 20 healthy controls were studied. The influence of HIV load, bacterial translocation (measured by 16S rDNA and lipopolysaccharide-binding protein) and immune activation markers (interleukin -IL- 6, soluble CD14, activated T cells) was analyzed. The absolute numbers and percentages of pDC and mDC were significantly increased in patients. Patients with detectable viral load exhibited increased intracellular expression of IL-12 by mDCs and interferon -IFN- α by pDCs. Activated population markers were elevated, and the proportion of Tregs was significantly higher in HIV-infected patients. The MDSC percentage was similar in patients and controls, but the intracellular expression of IL-10 was significantly higher in patients. The achievement of undetectable HIV load after therapy did not modify bacterial translocation parameters, but induce an increase in pDCs, mDCs and MDSCs only in recently infected patients. Our data support the importance of early antiretroviral therapy to preserve dendritic and regulatory cell function in HIV-infected individuals.
PB Nature Publishing Group
YR 2019
FD 2019-07-29
LK http://hdl.handle.net/10668/14388
UL http://hdl.handle.net/10668/14388
LA en
NO Márquez-Coello M, Montes de Oca Arjona M, Martín-Aspas A, Guerrero Sánchez F, Fernández-Gutiérrez Del Álamo C, Girón-González JA. Antiretroviral therapy partially improves the abnormalities of dendritic cells and lymphoid and myeloid regulatory populations in recently infected HIV patients. Sci Rep. 2019 Aug 12;9(1):11654
NO Tis work was supported by the Instituto de Salud Carlos III (Grant number PI11/00605). José A. Girón-González received a grant for “Intensifcación de Actividad Investigadora” 2013, Servicio Andaluz de Salud, Spain.
DS RISalud
RD Apr 10, 2025