RT Journal Article
T1 Prognostic impact of misdiagnosis of cardiac channelopathies as epilepsy.
A1 Ramos-Maqueda, Javier
A1 Bermúdez-Jiménez, Francisco
A1 Ruiz, Rosa Macías
A1 Ramos, Mercedes Cabrera
A1 Lerma, Manuel Molina
A1 Millán, Pablo Sánchez
A1 López, Miguel Álvarez
A1 Sánchez, Luis Tercedor
A1 Jiménez-Jáimez, Juan
AB Cardiac channelopathies are a frequent cause of sudden cardiac death (SCD) and often manifest with convulsive syncope, leading to a misdiagnosis of epilepsy. We aim to evaluate the clinical impact of epilepsy misdiagnosis in a cohort of patients with cardiac channelopathies. Fifty probands/families with a cardiac channelopathy were included. We retrospectively collected information from medical records to identify all patients who presented with convulsive syncope and were diagnosed with epilepsy after neurological evaluation. Clinical data and outcome were compared with those of patients without a previous epilepsy diagnosis. Eight patients had a previous diagnosis of epilepsy. At first episode, 3 of them presented a positive family history of SCD and 5 showed a pathological electrocardiogram; half presented with sudden cardiac arrest (SCA) and the rest with recurrent syncope despite treatment with 1 or more anti-epileptic drugs. Five patients had long QT syndrome, 2 had catecholaminergic polymorphic ventricular tachycardia, and 1 had Brugada syndrome. Epilepsy misdiagnosis was associated with an increased risk of SCA/SCD (OR 6.92, P = .04), a delay of 12 years (P = .047) in correct diagnosis, and a delay from first symptom to channelopathy diagnosis of 18.45 years (P  Cardiac channelopathy patients can be misdiagnosed with epilepsy. This involves a delayed diagnosis, a delay from the first symptom to a correct diagnosis, and an increased risk of SCA/SCD.
YR 2020
FD 2020-04-16
LK http://hdl.handle.net/10668/15381
UL http://hdl.handle.net/10668/15381
LA en
DS RISalud
RD Apr 10, 2025