RT Journal Article
T1 Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease.
A1 Sampedro, Frederic
A1 Martinez-Horta, Saul
A1 Horta-Barba, Andrea
A1 Grothe, Michel J
A1 Labrador-Espinosa, Miguel A
A1 Jesus, Silvia
A1 Adarmes-Gomez, Astrid
A1 Carrillo, Fatima
A1 Puig-Davi, Arnau
A1 Roldan-Lora, Florinda
A1 Aguilar-Barbera, Miquel
A1 Pastor, Pau
A1 Escalante-Arroyo, Sonia
A1 Solano-Vila, Berta
A1 Cots-Foraster, Anna
A1 Ruiz-Martinez, Javier
A1 Carrillo-Padilla, Francisco
A1 Pueyo-Morlans, Mercedes
A1 Gonzalez-Aramburu, Isabel
A1 Infante-Ceberio, Jon
A1 Hernandez-Vara, Jorge
A1 de-Fabregues-Boixar, Oriol
A1 de-Deus-Fonticoba, Teresa
A1 Avila, Asuncion
A1 Martínez-Castrillo, Juan Carlos
A1 Bejr-Kasem, Helena
A1 Campolongo, Antonia
A1 Pascual-Sedano, Berta
A1 Martinez-Martin, Pablo
A1 Santos-Garcia, Diego
A1 Mir, Pablo
A1 Garcia-Ruiz, Pedro J
A1 Kulisevsky, Jaime
K1 Parkinson's disease
K1 hypomimia
K1 neural
K1 neuroimage
K1 non-motor symptoms
AB Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.
PB Wiley-Blackwell Publishing Ltd.
YR 2022
FD 2022-11-02
LK http://hdl.handle.net/10668/19956
UL http://hdl.handle.net/10668/19956
LA en
NO Sampedro F, Martínez-Horta S, Horta-Barba A, Grothe MJ, Labrador-Espinosa MA, Jesús S, et al. Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease. Eur J Neurol. 2022 Dec;29(12):3720-3727.
DS RISalud
RD Apr 7, 2025