RT Journal Article
T1 ABCB1 gene polymorphisms and response to chemotherapy in breast cancer patients: A meta-analysis.
A1 Madrid-Paredes, Adela
A1 Cañadas-Garre, Marisa
A1 Sánchez-Pozo, Antonio
A1 Expósito-Ruiz, Manuela
A1 Calleja-Hernández, Miguel Ángel
K1 ABCB1
K1 Breast
K1 C1236T
K1 C3435T
K1 Cancer
K1 Meta-analysis
AB The ABCB1 gene encodes the P-glycoprotein, an efflux pump for some antineoplastic agents which acts as a resistance mechanism to chemotherapy. Three SNPs (C3435T, C1236T and G2677T/A), are the most widely studied in ABCB1. The inconsistent conclusions about the association of these polymorphisms and the response to chemotherapy in breast cancer (BC) patients prompted us to conduct a meta-analysis. A total of nine (770 patients), five (566 patients) and three studies (367 patients) relating the ABCB1 C3435T, C1236T and G2677T/A polymorphisms respectively, were included. The main analysis revealed a lack of association between ABCB1 polymorphisms and response to chemotherapy in every genetic model: C3435T (dominant OR: 0.888; 95%CI: 0.558-1.413), C1236T (dominant OR: 1.968; 95%CI: 0.609-6.362) and G2677T/A (GG vs GT + GA + TT + TA + AA OR: 0.854; 95%CI: 0.418-1.744). Stratification by ethnicity, cancer type and response criteria did not change the pattern of results. The available evidence indicates that three polymorphisms within ABCB1; C3435T, C1236T and G2677T/A, cannot be considered a reliable predictor of response to chemotherapy in BC patients.
YR 2017
FD 2017-09-21
LK http://hdl.handle.net/10668/11777
UL http://hdl.handle.net/10668/11777
LA en
DS RISalud
RD Apr 11, 2025