%0 Journal Article
%A Madrid-Paredes, Adela
%A Cañadas-Garre, Marisa
%A Sánchez-Pozo, Antonio
%A Expósito-Ruiz, Manuela
%A Calleja-Hernández, Miguel Ángel
%T ABCB1 gene polymorphisms and response to chemotherapy in breast cancer patients: A meta-analysis.
%D 2017
%U http://hdl.handle.net/10668/11777
%X The ABCB1 gene encodes the P-glycoprotein, an efflux pump for some antineoplastic agents which acts as a resistance mechanism to chemotherapy. Three SNPs (C3435T, C1236T and G2677T/A), are the most widely studied in ABCB1. The inconsistent conclusions about the association of these polymorphisms and the response to chemotherapy in breast cancer (BC) patients prompted us to conduct a meta-analysis. A total of nine (770 patients), five (566 patients) and three studies (367 patients) relating the ABCB1 C3435T, C1236T and G2677T/A polymorphisms respectively, were included. The main analysis revealed a lack of association between ABCB1 polymorphisms and response to chemotherapy in every genetic model: C3435T (dominant OR: 0.888; 95%CI: 0.558-1.413), C1236T (dominant OR: 1.968; 95%CI: 0.609-6.362) and G2677T/A (GG vs GT + GA + TT + TA + AA OR: 0.854; 95%CI: 0.418-1.744). Stratification by ethnicity, cancer type and response criteria did not change the pattern of results. The available evidence indicates that three polymorphisms within ABCB1; C3435T, C1236T and G2677T/A, cannot be considered a reliable predictor of response to chemotherapy in BC patients.
%K ABCB1
%K Breast
%K C1236T
%K C3435T
%K Cancer
%K Meta-analysis
%~