RT Journal Article
T1 Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.
A1 Singh, Bhagteshwar
A1 Lant, Suzannah
A1 Cividini, Sofia
A1 Cattrall, Jonathan W S
A1 Goodwin, Lynsey C
A1 Benjamin, Laura
A1 Michael, Benedict D
A1 Khawaja, Ayaz
A1 Matos, Aline de Moura Brasil
A1 Alkeridy, Walid
A1 Pilotto, Andrea
A1 Lahiri, Durjoy
A1 Rawlinson, Rebecca
A1 Mhlanga, Sithembinkosi
A1 Lopez, Evelyn C
A1 Sargent, Brendan F
A1 Somasundaran, Anushri
A1 Tamborska, Arina
A1 Webb, Glynn
A1 Younas, Komal
A1 Al Sami, Yaqub
A1 Babu, Heavenna
A1 Banks, Tristan
A1 Cavallieri, Francesco
A1 Cohen, Matthew
A1 Davies, Emma
A1 Dhar, Shalley
A1 Fajardo Modol, Anna
A1 Farooq, Hamzah
A1 Harte, Jeffrey
A1 Hey, Samuel
A1 Joseph, Albert
A1 Karthikappallil, Dileep
A1 Kassahun, Daniel
A1 Lipunga, Gareth
A1 Mason, Rachel
A1 Minton, Thomas
A1 Mond, Gabrielle
A1 Poxon, Joseph
A1 Rabas, Sophie
A1 Soothill, Germander
A1 Zedde, Marialuisa
A1 Yenkoyan, Konstantin
A1 Brew, Bruce
A1 Contini, Erika
A1 Cysique, Lucette
A1 Zhang, Xin
A1 Maggi, Pietro
A1 van Pesch, Vincent
A1 Lechien, Jérome
A1 Saussez, Sven
A1 Heyse, Alex
A1 Brito Ferreira, Maria Lúcia
A1 Soares, Cristiane N
A1 Elicer, Isabel
A1 Eugenín-von Bernhardi, Laura
A1 Ñancupil Reyes, Waleng
A1 Yin, Rong
A1 Azab, Mohammed A
A1 Abd-Allah, Foad
A1 Elkady, Ahmed
A1 Escalard, Simon
A1 Corvol, Jean-Christophe
A1 Delorme, Cécile
A1 Tattevin, Pierre
A1 Bigaut, Kévin
A1 Lorenz, Norbert
A1 Hornuss, Daniel
A1 Hosp, Jonas
A1 Rieg, Siegbert
A1 Wagner, Dirk
A1 Knier, Benjamin
A1 Lingor, Paul
A1 Winkler, Andrea Sylvia
A1 Sharifi-Razavi, Athena
A1 Moein, Shima T
A1 SeyedAlinaghi, SeyedAhmad
A1 JamaliMoghadamSiahkali, Saeidreza
A1 Morassi, Mauro
A1 Padovani, Alessandro
A1 Giunta, Marcello
A1 Libri, Ilenia
A1 Beretta, Simone
A1 Ravaglia, Sabrina
A1 Foschi, Matteo
A1 Calabresi, Paolo
A1 Primiano, Guido
A1 Servidei, Serenella
A1 Biagio Mercuri, Nicola
A1 Liguori, Claudio
A1 Pierantozzi, Mariangela
A1 Sarmati, Loredana
A1 Boso, Federica
A1 Garazzino, Silvia
A1 Mariotto, Sara
A1 Patrick, Kimani N
A1 Costache, Oana
A1 Pincherle, Alexander
A1 Klok, Frederikus A
A1 Meza, Roger
A1 Cabreira, Verónica
A1 Valdoleiros, Sofia R
A1 Oliveira, Vanessa
A1 Kaimovsky, Igor
A1 Guekht, Alla
A1 Koh, Jasmine
A1 Fernández Díaz, Eva
A1 Barrios-López, José María
A1 Guijarro-Castro, Cristina
A1 Beltrán-Corbellini, Álvaro
A1 Martínez-Poles, Javier
A1 Diezma-Martín, Alba María
A1 Morales-Casado, Maria Isabel
A1 García García, Sergio
A1 Breville, Gautier
A1 Coen, Matteo
A1 Uginet, Marjolaine
A1 Bernard-Valnet, Raphaël
A1 Du Pasquier, Renaud
A1 Kaya, Yildiz
A1 Abdelnour, Loay H
A1 Rice, Claire
A1 Morrison, Hamish
A1 Defres, Sylviane
A1 Huda, Saif
A1 Enright, Noelle
A1 Hassell, Jane
A1 D'Anna, Lucio
A1 Benger, Matthew
A1 Sztriha, Laszlo
A1 Raith, Eamon
A1 Chinthapalli, Krishna
A1 Nortley, Ross
A1 Paterson, Ross
A1 Chandratheva, Arvind
A1 Werring, David J
A1 Dervisevic, Samir
A1 Harkness, Kirsty
A1 Pinto, Ashwin
A1 Jillella, Dinesh
A1 Beach, Scott
A1 Gunasekaran, Kulothungan
A1 Rocha Ferreira Da Silva, Ivan
A1 Nalleballe, Krishna
A1 Santoro, Jonathan
A1 Scullen, Tyler
A1 Kahn, Lora
A1 Kim, Carla Y
A1 Thakur, Kiran T
A1 Jain, Rajan
A1 Umapathi, Thirugnanam
A1 Nicholson, Timothy R
A1 Sejvar, James J
A1 Hodel, Eva Maria
A1 Brain Infections Global COVID-Neuro Network Study Group, 
A1 Tudur Smith, Catrin
A1 Solomon, Tom
AB Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region. Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission.
YR 2022
FD 2022-06-02
LK http://hdl.handle.net/10668/20418
UL http://hdl.handle.net/10668/20418
LA en
DS RISalud
RD Apr 6, 2025