RT Journal Article
T1 Late Administration of Trastuzumab Emtansine Might Lead to Loss of Chance for Better Outcome in Patients with HER2-Positive Metastatic Breast Cancer.
A1 Manso, Luis
A1 Sanchez-Muñoz, Alfonso
A1 Calvo, Isabel
A1 Izarzugaza, Yann
A1 Plata, Jessica
A1 Rodriguez, Cesar
K1 Antineoplastic agents
K1 HER2-positive
K1 Loss of chance
K1 Metastatic breast cancer
K1 Oncologists
K1 Trastuzumab emtansine
AB The optimal sequence of anti-human epidermal growth factor receptor 2 (HER2) therapies in metastatic breast cancer (MBC) is still undetermined. Physicians must therefore make decisions based on clinical trials and their own experience for the best treatment sequence in these patients. The objective of this review is to summarize the efficacy and safety data for trastuzumab emtansine (T-DM1) in patients with MBC. Additionally, the concept of 'loss of chance for a better outcome' is investigated. It applies to patients who are not receiving the best possible treatment for their disease. Physicians should strive to offer the best possible care, although getting optimal results in each individual patient is not guaranteed. Lastly, the number of patients with MBC lost per treatment line is evaluated. We conclude that both concepts reinforce the importance of giving the most active treatments as soon as possible in the course of disease to secure the longest possible survival for HER2-positive MBC patients.
SN 1661-3791
YR 2018
FD 2018-07-13
LK http://hdl.handle.net/10668/13080
UL http://hdl.handle.net/10668/13080
LA en
DS RISalud
RD Apr 9, 2025