RT Journal Article
T1 Next Generation Probiotics for Neutralizing Obesogenic Effects: Taxa Culturing Searching Strategies
A1 López-Moreno, Ana
A1 Acuña, Inmaculada
A1 Torres-Sánchez, Alfonso
A1 Ruiz-Moreno, Ángel
A1 Cerk, Klara
A1 Rivas, Ana
A1 Suárez, Antonio
A1 Monteoliva-Sánchez, Mercedes
A1 Aguilera, Margarita
K1 Next-generation probiotics
K1 Culturing
K1 Dietary obesogens exposure
K1 Obesity
K1 Endocrine pathogenesis
K1 Endobolome
K1 Dysbiosis
K1 Probióticos
K1 Obesidad
K1 Disbiosis
K1 Bifidobacterium
K1 Lactobacillus
AB The combination of diet, lifestyle, and the exposure to food obesogens categorized into "microbiota disrupting chemicals" (MDC) could determine obesogenic-related dysbiosis and modify the microbiota diversity that impacts on individual health-disease balances, inducing altered pathogenesis phenotypes. Specific, complementary, and combined treatments are needed to face these altered microbial patterns and the specific misbalances triggered. In this sense, searching for next-generation beneficial microbes or next-generation probiotics (NGP) by microbiota culturing, and focusing on their demonstrated, extensive scope and well-defined functions could contribute to counteracting and repairing the effects of obesogens. Therefore, this review presents a perspective through compiling information and key strategies for directed searching and culturing of NGP that could be administered for obesity and endocrine-related dysbiosis by (i) observing the differential abundance of specific microbiota taxa in obesity-related patients and analyzing their functional roles, (ii) developing microbiota-directed strategies for culturing these taxa groups, and (iii) applying the successful compiled criteria from recent NGP clinical studies. New isolated or cultivable microorganisms from healthy gut microbiota specifically related to obesogens' neutralization effects might be used as an NGP single strain or in consortia, both presenting functions and the ability to palliate metabolic-related disorders. Identification of holistic approaches for searching and using potential NGP, key aspects, the bias, gaps, and proposals of solutions are also considered in this review.
PB MDPI
YR 2021
FD 2021-05-12
LK http://hdl.handle.net/10668/4046
UL http://hdl.handle.net/10668/4046
LA en
NO López-Moreno A, Acuña I, Torres-Sánchez A, Ruiz-Moreno Á, Cerk K, Rivas A, et al. Next Generation Probiotics for Neutralizing Obesogenic Effects: Taxa Culturing Searching Strategies. Nutrients. 2021 May 12;13(5):1617
DS RISalud
RD Apr 7, 2025