RT Journal Article
T1 The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients.
A1 Ribera, Jordi
A1 Granada, Isabel
A1 Morgades, Mireia
A1 Vives, Susana
A1 Genescà, Eulàlia
A1 González, Celia
A1 Nomdedeu, Josep
A1 Escoda, Lourdes
A1 Montesinos, Pau
A1 Mercadal, Santiago
A1 Coll, Rosa
A1 González-Campos, José
A1 Abella, Eugenia
A1 Barba, Pere
A1 Bermúdez, Arancha
A1 Gil, Cristina
A1 Tormo, Mar
A1 Pedreño, María
A1 Martínez-Carballeira, Daniel
A1 Hernández-Rivas, Jesús-María
A1 Orfao, Alberto
A1 Martínez-López, Joaquín
A1 Esteve, Jordi
A1 Bravo, Pilar
A1 Garcia-Guiñon, Antoni
A1 Debén, Guillermo
A1 Moraleda, José M
A1 Queizán, José A
A1 Ortín, Xavier
A1 Moreno, María J
A1 Feliu, Evarist
A1 Solé, Francesc
A1 Ribera, Josep M
A1 PETHEMA Group, Spanish Society of Haematology
K1 acute lymphoblastic leukaemia
K1 adults
K1 age
K1 hypodiploidy
K1 prognosis
AB The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
YR 2019
FD 2019-03-27
LK http://hdl.handle.net/10668/13761
UL http://hdl.handle.net/10668/13761
LA en
DS RISalud
RD Apr 14, 2025