%0 Journal Article
%A Ribera, Jordi
%A Granada, Isabel
%A Morgades, Mireia
%A Vives, Susana
%A Genescà, Eulàlia
%A González, Celia
%A Nomdedeu, Josep
%A Escoda, Lourdes
%A Montesinos, Pau
%A Mercadal, Santiago
%A Coll, Rosa
%A González-Campos, José
%A Abella, Eugenia
%A Barba, Pere
%A Bermúdez, Arancha
%A Gil, Cristina
%A Tormo, Mar
%A Pedreño, María
%A Martínez-Carballeira, Daniel
%A Hernández-Rivas, Jesús-María
%A Orfao, Alberto
%A Martínez-López, Joaquín
%A Esteve, Jordi
%A Bravo, Pilar
%A Garcia-Guiñon, Antoni
%A Debén, Guillermo
%A Moraleda, José M
%A Queizán, José A
%A Ortín, Xavier
%A Moreno, María J
%A Feliu, Evarist
%A Solé, Francesc
%A Ribera, Josep M
%A PETHEMA Group, Spanish Society of Haematology
%T The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients.
%D 2019
%U http://hdl.handle.net/10668/13761
%X The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
%K acute lymphoblastic leukaemia
%K adults
%K age
%K hypodiploidy
%K prognosis
%~