RT Journal Article
T1 Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review
A1 Paris, Juan L.
A1 Vallet-Regi, Maria
K1 Mesoporous silica nanoparticles
K1 Co-delivery
K1 Drug delivery
K1 Nucleic acids
K1 Gene transfection
K1 Nanomedicine
AB Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural properties, which provide a great loading capacity for many types of cargos. In the context of cancer nanomedicine, combination therapy and gene transfection/silencing have recently been highlighted as two of its most promising fields. In this review, we aim to provide an overview of the different small molecule drug-nucleic acid co-delivery combinations that have been developed using mesoporous silica nanoparticles as carriers. By carefully selecting the chemotherapeutic drug and nucleic acid cargos to be co-delivered by mesoporous silica nanoparticles, different therapeutic goals can be achieved by overcoming resistance mechanisms, combining different cytotoxic mechanisms, or providing an additional antiangiogenic effect. The examples here presented highlight the great promise of this type of strategies for the development of future therapeutics.
PB MDPI
YR 2020
FD 2020-06-08
LK http://hdl.handle.net/10668/3585
UL http://hdl.handle.net/10668/3585
LA en
NO Paris JL, Vallet-Regí M. Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review. Pharmaceutics. 2020 Jun 8;12(6):526
DS RISalud
RD Apr 7, 2025