RT Journal Article
T1 Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial.
A1 Ruiz-Canela, Miguel
A1 Guasch-Ferré, Marta
A1 Toledo, Estefanía
A1 Clish, Clary B
A1 Razquin, Cristina
A1 Liang, Liming
A1 Wang, Dong D
A1 Corella, Dolores
A1 Estruch, Ramón
A1 Hernáez, Álvaro
A1 Yu, Edward
A1 Gómez-Gracia, Enrique
A1 Zheng, Yan
A1 Arós, Fernando
A1 Romaguera, Dora
A1 Dennis, Courtney
A1 Ros, Emilio
A1 Lapetra, José
A1 Serra-Majem, Lluis
A1 Papandreou, Christopher
A1 Portoles, Olga
A1 Fitó, Montserrat
A1 Salas-Salvadó, Jordi
A1 Hu, Frank B
A1 Martínez-González, Miguel A
K1 Aromatic amino acids
K1 Branched-chain amino acids
K1 Mediterranean diet
K1 Type 2 diabetes
AB Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 ( www.controlled-trials.com ).
YR 2018
FD 2018-04-16
LK http://hdl.handle.net/10668/12358
UL http://hdl.handle.net/10668/12358
LA en
DS RISalud
RD Apr 11, 2025