%0 Journal Article
%A Ruiz-Canela, Miguel
%A Guasch-Ferré, Marta
%A Toledo, Estefanía
%A Clish, Clary B
%A Razquin, Cristina
%A Liang, Liming
%A Wang, Dong D
%A Corella, Dolores
%A Estruch, Ramón
%A Hernáez, Álvaro
%A Yu, Edward
%A Gómez-Gracia, Enrique
%A Zheng, Yan
%A Arós, Fernando
%A Romaguera, Dora
%A Dennis, Courtney
%A Ros, Emilio
%A Lapetra, José
%A Serra-Majem, Lluis
%A Papandreou, Christopher
%A Portoles, Olga
%A Fitó, Montserrat
%A Salas-Salvadó, Jordi
%A Hu, Frank B
%A Martínez-González, Miguel A
%T Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial.
%D 2018
%U http://hdl.handle.net/10668/12358
%X Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 ( www.controlled-trials.com ).
%K Aromatic amino acids
%K Branched-chain amino acids
%K Mediterranean diet
%K Type 2 diabetes
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