RT Journal Article
T1 Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Biomarkers of Oxidative Stress and Inflammation in Healthy Adults: A Randomized Double-Blind Controlled Trial.
A1 Sanchez-Rodriguez, Estefania
A1 Biel-Glesson, Sara
A1 Fernandez-Navarro, Jose R
A1 Calleja, Miguel A
A1 Espejo-Calvo, Juan A
A1 Gil-Extremera, Blas
A1 de la Torre, Rafael
A1 Fito, Montserrat
A1 Covas, Maria-Isabel
A1 Vilchez, Pedro
A1 Alche, Juan de Dios
A1 Martinez de Victoria, Emilio
A1 Gil, Angel
A1 Mesa, Maria D
K1 8-hidroxy-2′-deoxyguanosine
K1 TNF-alpha
K1 cardiovascular diseases
K1 interleukin-8
K1 maslinic acid
K1 oleanolic acid
K1 olive oil
K1 oxidative stress
K1 phenolic compounds
K1 triterpenes
K1 virgin olive oil
AB A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 389 ppm of triterpenes) supplementation (30 mL per day) during three weeks would provide additional health benefits to those produced by a standard VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes) on oxidative and inflammatory biomarkers. Fifty-one healthy adults participated in a randomized, crossover, and controlled study. Urinary 8-hidroxy-2'-deoxyguanosine, plasma interleukin-8 (IL-8), and tumor necrosis factor α (TNF- α) concentrations were lower after the intervention with the FOO than after the OVOO (p = 0.033, p = 0.011 and p = 0.020, respectively). In addition, IL-8 was lower after the intervention with FOO than after VOO intervention (p = 0.002). This study provides a first level of evidence on the in vivo health benefits of olive oil triterpenes (oleanolic and maslinic acids) in healthy humans, decreasing DNA oxidation and plasma inflammatory biomarkers. The trial was registered in ClinicalTrials.gov ID: NCT02520739.
YR 2019
FD 2019-03-06
LK http://hdl.handle.net/10668/13672
UL http://hdl.handle.net/10668/13672
LA en
DS RISalud
RD Apr 7, 2025