%0 Journal Article
%A Meza, Giovanna
%A Galián, Fátima
%A Jaimes-Bernal, Claudia
%A Márquez, Francisco J
%A Sinangil, Faruk
%A Scagnolari, Carolina
%A Real, Luis Miguel
%A Forthal, Donald
%A Caruz, Antonio
%T IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men.
%D 2022
%U http://hdl.handle.net/10668/19694
%X Individuals lacking interferon lambda 4 (IFNL4) protein due to a common null mutation (rs368234815) in the IFNL4 gene display higher resistance against several infections. The influence of IFNL4 on HIV-1 infection is still under discussion and conflicting results have been reported. This study intended to corroborate or refute the association of the null allele of IFNL4 and HIV-1 predisposition in a cohort of men who have sex with men (MSM). IFNL4 null genotype was assessed on 619 HIV-1-seronegative MSM who were followed for 36 months during a trial of a prophylactic vaccine against HIV-1. Of those, 257 individuals seroconverted during this period. A logistic regression model was constructed including demographic and IFNL4 genotype. In addition, a meta-analysis using data from the current study and other European populations was conducted. The null IFNL4 genotypes were correlated with lower HIV-1 seroconversion (Adjusted OR = 0.4 [95%CI: 0.2-0.8], P = 0.008) and longer time to seroconversion (889 vs. 938 days, P= 0.01). These results were validated by a meta-analysis incorporating data from other European populations and the result yielded a significant association of the IFNL4 null genotype under a dominant model with a lower probability of HIV-1 infection (OR=0.4 [95% CI: 0.3-0.6]; P= 1.3 x 10E-5).
%K HESN
%K HIV exposed seronegative
%K HIV-1
%K IFNL4
%K IL28B
%~