TY - JOUR AU - Horrillo, A AU - Pezzolla, D AU - Fraga, M F AU - Aguilera, Y AU - Salguero-Aranda, C AU - Tejedo, J R AU - Martin, F AU - Bedoya, F J AU - Soria, B AU - Hmadcha, A PY - 2013 DO - 10.1038/cddis.2013.88 UR - http://hdl.handle.net/10668/2254 T2 - Cell Death & Disease AB - Lineage commitment during embryonic stem cell (ESC) differentiation is controlled not only by a gamut of transcription factors but also by epigenetic events, mainly histone deacetylation and promoter DNA methylation. The DNA demethylation agent... LA - en PB - Nature Publishing Group KW - Embryonic stem cells KW - Methylation KW - Mesoderm KW - Zebularine KW - AzadC KW - Nitric oxide KW - Células madre embrionaria KW - Metilación KW - Mesodermo KW - Línea celular KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biomarkers KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Ribonucleosides::Cytidine KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation KW - Medical Subject Headings::Anatomy::Cells::Stem Cells::Embryonic Stem Cells::Embryoid Bodies KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Developmental KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Metabolic Networks and Pathways KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Anatomy::Cells::Muscle Cells::Myocytes, Cardiac KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction TI - Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment. TY - research article ER -