RT Journal Article
T1 Collinsella is associated with cumulative inflammatory burden in an established rheumatoid arthritis cohort.
A1 Ruiz-Limon, Patricia
A1 Mena-Vazquez, Natalia
A1 Moreno-Indias, Isabel
A1 Manrique-Arija, Sara
A1 Lisbona-Montañez, Jose Manuel
A1 Cano-Garcia, Laura
A1 Tinahones, Francisco J
A1 Fernandez-Nebro, Antonio
K1 Collinsella
K1 Cumulative inflammatory burden
K1 Gut microbiota
K1 Inflammation
K1 Rheumatoid arthritis
AB To analyze the gut microbiota of patients with rheumatoid arthritis (RA) according to disease activity. An observational cross-sectional study of 110 patients with RA and 110 age- and sex-matched controls was performed. Patients were classified according to the disease activity (DAS28 ≥3.2 or DAS28  The mean DAS28 indicated remission/low inflammatory activity in 71 patients (64.5 %) and moderate/high activity in 39 (35.5 %) during follow-up. Alpha and beta diversity analysis revealed differences in gut microbiota between the 3 study groups. In the moderate/high activity RA, we observed a significant change in the abundance of genera compared with the other groups. The abundance of Collinsella and Bifidobacterium was increased in RA patients compared with controls. The metabolic profile of gut microbiota was characterized by differences in pathways related to Biosynthesis, Generation of Precursor Metabolites/Energy, and Degradation/Utilization/Assimilation between the 3 groups. The factors associated with cumulative inflammatory activity in RA were age (OR [95 % CI], 1.065 [1.002-1.131]), obesity (OR [95% CI], 3.829 [1.064-8.785]), HAQ score (OR [95% CI], 2.729 [1.240-5.009]), and expansion of the genus Collinsella (OR [95% CI], 3.000 [1.754-9.940]). The composition of gut microbiota differed between patients with RA and moderate/high activity, patients with remission/low activity, and controls. The genus Collinsella, age, obesity, and physical function were associated with cumulative inflammatory burden in RA.
PB Elsevier
YR 2022
FD 2022-08-06
LK http://hdl.handle.net/10668/22047
UL http://hdl.handle.net/10668/22047
LA en
NO Ruiz-Limón P, Mena-Vázquez N, Moreno-Indias I, Manrique-Arija S, Lisbona-Montañez JM, Cano-García L, et al. Collinsella is associated with cumulative inflammatory burden in an established rheumatoid arthritis cohort. Biomed Pharmacother. 2022 Sep;153:113518
NO This work was supported by Instituto Salud Carlos III (grants cofunded by ERDF) (PI18/00824). The research groups belong to the “Centros de Investigación en Red” (CIBERobn), of the Instituto de Salud Carlos III. The authors thank the Metagenomic Platform of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), Spain, and, especially, Pablo Rodríguez. PRL was supported by a “Sara Borrell” postdoctoral contract (CD19/00216) from the ISCIII-Madrid (Spain), co-funded by the Fondo Europeo de Desarrollo Regional-FEDER. IMI was supported by the "Miguel Servet Type II" program (CPII21/00013) of the ISCIII-Madrid (Spain). "Ayuda de Garantía Juvenil 2020" of the University of Malaga, Spain (SNGJ5Y6–12).
DS RISalud
RD Apr 12, 2025