RT Journal Article
T1 Cholinergic regulation of bone.
A1 Eimar, H
A1 Tamimi, I
A1 Murshed, M
A1 Tamimi, F
K1 Cholinergic
K1 Parasympathetic Nervous System
K1 Bone
K1 Acetylcholine
K1 Osteoporosis
K1 Vías autónomas
K1 Remodelación Ósea
K1 Sistema nervioso central
K1 Humanos
AB Bone remodeling is regulated by the two branches of the autonomic nervous system: the adrenergic and the cholinergic branches. Adrenergic activity favors bone loss, whereas cholinergic activity has been recently shown to favor bone mass accrual. In vitro studies have reported that cholinergic activity induces proliferation and differentiation of bone cells. In vivo studies have shown that the inhibition of cholinergic activity favors bone loss, whereas its stimulation favors bone mass accrual. Clinical studies have shown that bone density is associated with the function of many cholinergic-regulated tissues such as the hypothalamus, salivary glands, lacrimal glands and langerhans cells, suggesting a common mechanism of control. Altogether, these observations and linked findings are of great significance since they improve our understanding of bone physiology. These discoveries have been successfully used recently to investigate new promising therapies for bone diseases based on cholinergic stimulation. Here, we review the current understanding of the cholinergic activity and its association with bone health.
SN 1108-7161
YR 2013
FD 2013-06
LK http://hdl.handle.net/10668/1503
UL http://hdl.handle.net/10668/1503
LA en
NO Eimar H, Tamimi I, Murshed M, Tamimi F. Cholinergic regulation of bone. J Musculoskelet Neuronal Interact. 2013; 13(2):124-32
NO Journal Article; Research Support, Non-U.S. Gov't; Review;
DS RISalud
RD Apr 20, 2025