RT Journal Article
T1 Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial.
A1 Laguna, Juan C
A1 Alegret, Marta
A1 Cofán, Montserrat
A1 Sánchez-Tainta, Ana
A1 Díaz-López, Andrés
A1 Martínez-González, Miguel A
A1 Sorlí, José V
A1 Salas-Salvadó, Jordi
A1 Fitó, Montserrat
A1 Alonso-Gómez, Ángel M
A1 Serra-Majem, Lluís
A1 Lapetra, José
A1 Fiol, Miquel
A1 Gómez-Gracia, Enrique
A1 Pintó, Xavier
A1 Muñoz, Miguel A
A1 Castañer, Olga
A1 Ramírez-Sabio, Judith B
A1 Portu, José J
A1 Estruch, Ramón
A1 Ros, Emilio
K1 Dietary sugar
K1 Fructose
K1 Fruit juice
K1 Glucose
K1 Liquid form
K1 Observational study
AB To examine associations between intake of simple sugars and cancer incidence, cancer mortality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 ± 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality.
YR 2021
FD 2021-08-10
LK https://hdl.handle.net/10668/24806
UL https://hdl.handle.net/10668/24806
LA en
DS RISalud
RD Apr 19, 2025