TY  - JOUR
AU  - Escudero-Contreras, Alejandro
AU  - López-Medina, Clementina
AU  - Collantes-Estévez, Eduardo
AU  - Ortega-Castro, Rafaela
AU  - Calvo-Gutiérrez, Jerusalem
AU  - Mena-Vázquez, Natalia
AU  - Panero-Lamothe, Blanca
AU  - Manzanares-Martín, Bárbara
AU  - Cáliz-Cáliz, Rafael
AU  - Jiménez-Morales, Alberto
AU  - Ruiz-Jiménez, Mayte
AU  - Font-Ugalde, Pilar
PY  - 2021
DO  - 10.3390/jcm10184070
UR  - http://hdl.handle.net/10668/3959
T2  - Journal of Clinical Medicine
AB  - Objective: to identify new single-nucleotide polymorphisms (SNPs) in genes encoding proteins involved in methotrexate (MTX) metabolism and to evaluate the associations of these SNPs with MTX toxicity or intolerance in a southern Spanish cohort of...
LA  - en
PB  - MDPI
KW  - Methotrexate
KW  - Rheumatoid arthritis
KW  - Genetics
KW  - Biomarkers
KW  - Metotrexato
KW  - Genetic polymorphisms
KW  - Genotype
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Pteridines::Pterins::Aminopterin::Methotrexate
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies
KW  - Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
KW  - Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic
TI  - Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis
TY  - research article
ER  -